Titel: Statistical methods for identification of genes under natural selection

Termin: 15.5.2006 bis 19.5.2006

Veranstaltungsort:
University of Helsinki
computer centre (Aleksandria)

Referenten: Mark Beaumot (School of Animal and Microbial Sciences, University of Reading, UK) *** Jukka Corander (University of Helsinki, Finland) *** Joachim Hermisson ( Department of Biologie II, University of Munich, Germany) *** Christian Schlötterer ( University of Veterinary Medicine, Vienna, Austria) *** Ziheng Yang ( Department of Biology, University College London, UK)

Weitere Informationen:
http://cwp.embo.org/pc06-02/

Kurzbeschreibung: The identification of genes subjected to natural selection has been one of the primary research interests in population genetics over the past decades. With the recent technological advancements and the availability of numerous fully sequenced genomes, the emphasis is shifting from the analysis of single genes towards genome scans for genes subjected to selection.

Information about whether or not a gene has been subjected to natural selection could be used to learn more about the function of the gene, in particular if the selective forces are known (e.g. selection in domestic animals, insecticide resistance etc.). Therefore, an increasing number of molecular biologists are becoming interested to apply statistical tests for the identification of selected genes (or selected amino acids) to the gene of their interest. On the other hand, the large amount of data that are currently produced (e.g. the sequence of 50 completely sequenced D. melanogaster genomes will become available shortly) also requires new approaches for the identification of selected genes.

The proposed course aims to train molecular biologists with the fundamental techniques on how to use statistical methods for the identification of selected genes. Furthermore, we will also show how the statistical tests could be improved by the incorporation of available data from genome scans.

Participants of the course will be provided with the background of the statistical tests, they will be trained in the use of available statistical software packages, and finally they will have the opportunity to apply this knowledge to their own data.

Kontakt: Mrs Jukka Corander
Department of Mathematics and Statistics
Faculty of Social Science
University of Helsinki
P.O. Box 68
00014 Helsinki
Finland
Tel.: +358 - 9 - 19 15 14 20
Fax: +358 - 9 - 19 15 14 00
Jukka.Corander@rni.helsinki.fi
http://mathstat.helsinki.fi/

Veranstalter: University of Helsinki - Department of Mathematics and Statistics, University of Veterinary Medicine (Vienna, Austria)

Schlagworte: Genetische Tests/Beratung, Genforschung/-technik, Genomanalyse, Humangenetik