Titel: Stemness: the bright and the dark side. Normal and cancer stem cells

Termin: 19.9.2006, 13:00 Uhr, bis 22.9.2006, 15:30 Uhr

Veranstaltungsort:
Meeting:

Hotel Estella Residence
addressVia Delle Provincie, 37
88060 Montepaone

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Final Session:

University of Catanzaro ‘Magna Græcia’
Lecture Hall

Referenten: Allison Blair ( Bristol Institute for Transfusion Sciences, Bristol, UK) *** Dominique Bonnet ( London Research Institute, London, UK) *** Robert B. Clarke (University of Manchester, UK) *** Hans Clevers (Hubrecht Institute, Utrecht, NL) *** Pier Paolo Di Fiore (IFOM-IEO, Milan, Italy) *** Peter Dirks ( The Hospital for Sick Children, Toronto, Canada) *** Gabriela Dontu ( University of Michigan, Medical School, Ann Arbor, MI – USA) *** Ruggero De Maria ( Istituto Superiore di Sanità, Rome, Italy) *** Tariq Enver (The Weatherall Institute of Molecular Medicine, Oxford, UK) *** Tessa L. Holyoake (University of Glasgow, UK) *** Craig T. Jordan ( University of Rochester, NY, USA) *** Anna M. Kenney ( Memorial Sloan-Kettering Cancer Center, New York, NY - USA) *** Rohit Lal (London Research Institute, London, UK) *** Tsvee Lapidot (Weizmann Institute of Science, Rehovot, Israel) *** Maarten van Lohuizen (The Netherlands Cancer Institute, Amsterdam, NL) *** Norman J. Maitland (University of York, UK) *** William Matsui (The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD – USA) *** Malcolm A.S. Moore ( Memorial Sloan-Kettering Cancer Center, New York, NY - USA) *** Giovanni Morrone (University of Catamzaro Magna Græcia, Catanzaro, Italy) *** Sean J. Morrison (University of Michigan Medical School, Ann Arbor, MI - USA) *** Claus Nerlov (EMBL Monterotondo, Italy) *** Timothy C. Wang (Columbia University, New York, NY – USA)

Weitere Informationen:
http://cwp.embo.org/w06-39/

Kurzbeschreibung: In the recent past it has become increasingly evident that stem cells are present in several adult organs and tissues and can generate their diverse cellular components. These cells hold great promise in regenerative medicine and a better understanding of their biology will be critical for their application.

A wealth of recent experimental evidence also supports the notion that at least many types of cancers possess a hierarchical structure whereby a minute sub-population of tumour stem cells is responsible for the development and the maintenance of cancer. These cells, that exhibit distinct features in terms of antigenic profile, proliferative status, self-renewal potential and drug sensitivity, may be considered the ultimate target of cancer therapy.

Despite the rapid progress of cancer stem cell research, numerous issues await further elucidation, such as:

* complexity and heterogeneity of cancer stem cell compartment;

* cellular targets of the transforming events;

* role of the microenvironment in the regulation of the neoplastic stem cells;

* control of survival, apoptosis and self-renewal: analogies and differences with the normal counterpart;

* homing of cancer stem cells and generation of metastases;

* strategies for selective targeting of cancer stem cells, and for monitoring their eradication.

These issues will be discussed in the meeting, that is expected to be of interest for stem cell and cancer biologists, and clinical investigators engaged in the development of innovative approaches for cancer prevention and treatment.

The official language of the Workshop will be English.

Kontakt: Mr Giovanni Morrone
Department of Experimental and Clinical Medicine
University of Catanzaro Magna Græcia
Via Tommaso Campanella 115
88100 Catanzaro
Italy
Tel.: +39 - 0961 - 3 69 40 72
morrone@unicz.it

Veranstalter: University of Catanzaro Magna Græcia

Schlagworte: Embryonale Stammzellen, Genetische Tests/Beratung, Genforschung/-technik, Gesundheitswesen, Humangenetik, Krankheit, Organ-/Gewebetransplantation