Titel: Cellular and Molecular Basis of Regeneration and Tissue repair

Termin: 10.9.2006 bis 15.9.2006

Veranstaltungsort:
Centro Stefano Franscini
Monte Verità
Via Collina
6612 Ascona
Switzerland

Referenten: Kiyo AGATA (Kyoto, Japan) *** Marie André AKIMENKO (Ottawa, Canada) *** Guillermo BARRETO (Heidelberg, Germany) *** Michael BRAND (Dresden, Germany) *** Jeremy BROCKES (London, UK) *** Margaret BUCKINGHAM (Paris, France) *** Danielle DHOUAILLY (Grenoble, France) *** Brigitte GALLIOT (Geneva, Switzerland) *** Gideon GRAFI (Rehovot, Israel) *** Thomas HOLSTEIN (Heidelberg, Germany) *** Toru KONDO (Kobe, Japan) *** Pierre LEOPOLD (Nice University, France) *** Renato PARO (Heidelberg, Germany) *** Kenneth POSS (Durham, USA) *** Nadia ROSENTHAL (Monterotondo, Italy) *** Leonardo ROSSI (Pisa, Italy) *** Michael RUDNICKI (Ottawa, Canada) *** Alejandro SANCHEZ ALVARADO (Salt Lake City, USA) *** Gerold SCHUBIGER (Seattle, USA) *** Andras SIMON (Stockholm, Sweden) *** Jonathan SLACK (Bath, UK) *** Didier STAINIER (San Francisco, USA) *** Elly TANAKA (Dresden, Germany) *** David TOSH (Bath, UK) *** Andreas TRUMPP (Lausanne, Switzerland) *** Panagiotis TSONIS (Dayton, USA)

Weitere Informationen:
http://www.regeneration2006.unige.ch/

Kurzbeschreibung: The aim of this conference is to provide a multidisciplinary and integrative platform on the cellular and molecular basis of regeneration and tissue repair. The ability of an adult organism to undergo regeneration and functional repair is present in all multicellular phyla. Planaria and hydra can regenerate entire organisms from small tissue fragments or cellular aggregates. Urodele amphibians regenerate limbs, jaws, and tails including the spinal cord, zebrafish regenerates fins and can repair damaged cardiac tissues. However, many other species, especially higher vertebrates do not respond to injury or tissue removal by re-growing missing body parts. Why is the regeneration phenomenon lost in these animals and could it be, at least to some extent, induced in the future?

Recent advances in the dissection of the regeneration processes have brought up molecular cues that allow comparisons between epimorphic and morphallactic regeneration. In addition, those molecular cues can be analyzed in the context of tissue repair in organisms traditionally considered as non-regenerating. Despite the apparent differences between various species, reserve cells have been identified in all organisms, and differentiated tissues like liver and muscle can to a certain degree be replaced de novo also in adult mammals. Progenitor cells for tissue repair and regeneration arise either by the activation of a reserve cell population or by local reversal of differentiation in cells close to the site of injury as exemplified in urodele amphibians. Nevertheless, little is known about the way cells maintain or reprogram their identity, how progenitor cells can be reactivated after injury, what are the factors and events that influence their choice of fate. These questions are critical issues to regeneration and cell plasticity.

By bringing together researchers representing various fields and model systems, this conference should help interlink the mechanisms of wounding response, subsequent generation of relevant precursor population, and morphogenesis to rebuild missing structures. Poster sessions are planned and time will be allotted to selected short oral contributions.

Kontakt: Mrs Brigitte Galliot, MD, PhD
Department of Zoology and Animal Biology
University of Geneva
Sciences III
30 quai Ernest Ansermet
1211 Geneve 4
Switzerland
Tel.: +41 - (0)22 - 3 79 67 74
Fax: +41 - (0)22 - 3 79 67 95
brigitte.galliot@zoo.unige.ch

Veranstalter: Department of Zoology and Animal Biology - University of Geneva (Geneva, Switzerland), Max Planck Institute of Molecular Cell Biology and Genetics (Dresden, Germany), Karolinska Institute (Stockholm, Sweden)

Wissenschaftliche Leitung: Brigitte GALLIOT, MD, PhD (Department of Zoology and Animal Biology, University of Geneva, Switzerland), Elly TANAKA, PhD (Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany), András SIMON, PhD (Karolinska Institute, Medical Nobel Institute, Stockholm, Sweden)

Schlagworte: Embryonale Stammzellen, Genetische Tests/Beratung, Genforschung/-technik, Gentherapie, Humangenetik, Organ-/Gewebetransplantation